Complement-Activating Anti-HLA Antibodies in Kidney Transplantation: Allograft Gene Expression Profiling and Response to Treatment.

doi:10.1681/ASN.2017050589

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Article

Complement-Activating Anti-HLA Antibodies in Kidney Transplantation: Allograft Gene Expression Profiling and Response to Treatment.

Journal of the American Society of Nephrology : JASN - 1 Feb 2018

Lefaucheur Carmen, Viglietti Denis, Hidalgo Luis G, Ratner Lloyd E, Bagnasco Serena M, Batal Ibrahim, Aubert Olivier, Orandi Babak J, Oppenheimer Federico, Bestard Oriol, Rigotti Paolo, Reisaeter Anna V, Kamar Nassim, Lebranchu Yvon, Duong Van Huyen Jean-Paul, Bruneval Patrick, Glotz Denis, Legendre Christophe, Empana Jean-Philippe, Jouven Xavier, Segev Dorry L, Montgomery Robert A, Zeevi Adriana, Halloran Philip F, Loupy Alexandre

Abstract excerpt

Complement-activating anti-HLA donor-specific antibodies (DSAs) are associated with impaired kidney transplant outcome; however, whether these antibodies induce a specific rejection phenotype and influence response to therapy remains undetermined. We prospectively screened 931 kidney recipients for complement-activating DSAs and used histopathology, immunostaining, and allograft gene expression to assess...

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Identifiers

PMID: 29042454
DOI: 10.1681/ASN.2017050589
PMCID: PMC5791056

Genes

CCL4
CXCL11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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