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Evaluation of de novo donor specific antibodies after kidney transplantation in the era of donor-derived cell-free DNA

16 Jan 2025

Abstract excerpt

Background: donor-specific antibodies (dnDSA) are crucial in ABMR, the relationship between dd-cfDNA levels and dnDSA features, such as DSA category, MFI and HLA target loci, remains unclear. Methods: We analyzed dd-cfDNA levels in 75 kidney transplant recipients who developed dnDSA post-transplant. dnDSA were categorized as "true", "possible", or "false" based on bead reactivity patterns and HLA typing. dd-cfDNA...

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Share to Organ Transplantation Techniques and Outcomes
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PMID: 39885988
DOI: 10.3389/fimmu.2024.1530065

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