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PathoGD: an integrative genomics approach to primer and guide RNA design for CRISPR-based diagnostics

30 Jan 2025

Abstract excerpt

Critical to the success of CRISPR-based diagnostic assays is the selection of a diagnostic target highly specific to the organism of interest, a process often requiring iterative cycles of manual selection, optimisation, and redesign. Here we present PathoGD, a bioinformatic pipeline for rapid and high-throughput design of RPA primers and gRNAs for CRISPR-Cas12a-based pathogen detection. PathoGD is fully...

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PMID: 39885339
DOI: 10.1038/s42003-025-07591-1

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