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Deep learning enhancing guide RNA design for CRISPR/Cas12a‐based diagnostics

15 Jun 2024

Abstract excerpt

Abstract Rapid and accurate diagnostic tests are fundamental for improving patient outcomes and combating infectious diseases. The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) Cas12a‐based detection system has emerged as a promising solution for on‐site nucleic acid testing. Nonetheless, the effective design of CRISPR RNA (crRNA) for Cas12a‐based detection remains challenging and...

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PMID: 39135699
DOI: 10.1002/imt2.214

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