Desmosomal Cadherins and Signaling: Lessons from Autoimmune Disease

Abstract excerpt

Autoantibodies from patients suffering from the autoimmune blistering skin disease pemphigus can be applied as tools to study desmosomal adhesion. These autoantibodies targeting the desmosomal cadherins desmoglein (Dsg) 1 and Dsg3 cause disruption of desmosomes and loss of intercellular cohesion. Although pemphigus autoantibodies were initially proposed to sterically hinder desmosomes, many groups have shown that...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autoimmune Bullous Skin Diseases
• Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
• Share to Wnt/β-catenin signaling in development and cancer