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Article

Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster.

Behavior genetics - 1 May 2012

Stephens Sarah H, Hoft Nicole R, Schlaepfer Isabel R, Young Susan E, Corley Robin C, McQueen Matthew B, Hopfer Christian, Crowley Thomas, Stallings Michael, Hewitt John, Ehringer Marissa A

Abstract excerpt

There is strong evidence for shared genetic factors contributing to childhood externalizing disorders and substance abuse. Externalizing disorders often precede early substance experimentation, leading to the idea that individuals inherit a genetic vulnerability to generalized disinhibitory psychopathology. Genetic variation in the CHRNA5/CHRNA3/CHRNB4 gene cluster has been associated with early substance...

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Source

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Identifiers

PMID: 22042234
DOI: 10.1007/s10519-011-9514-x
PMCID: PMC3506120

Genes

CHRNA3
CHRNA5
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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