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Article

APP antisense oligonucleotides are effective in rescuing mitochondrial phenotypes in human iPSC-derived trisomy 21 astrocytes.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2025

Thirumalai Srishruthi, Livesey Frederick J, Patani Rickie, Hung Christy

Abstract excerpt

INTRODUCTION: Antisense oligonucleotides (ASOs) have shown promise in reducing amyloid precursor protein (APP) levels in neurons, but their effects in astrocytes, key contributors to neurodegenerative diseases, remain unclear. This study evaluates the efficacy of APP ASOs in astrocytes derived from an individual with Down syndrome (DS), a population at high risk for Alzheimer's disease (AD). METHODS: Human...

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Share to Amyloid beta-Protein Precursor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Down Syndrome

Share to Induced Pluripotent Stem Cells

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Share to Oligonucleotides, Antisense

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Source

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Identifiers

PMID: 39877983
DOI: 10.1002/alz.14560
PMCID: PMC11775556

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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