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Truncated DAZL mutation reduces NANOS3 expression in primordial germ cells and leads to premature ovarian insufficiency

9 Feb 2024

Abstract excerpt

Dear Editor, Premature ovarian insufficiency (POI) is defined as the dysfunction or deficiency of ovarian follicles in women younger than 40 years old [1]. Several factors, including genetic, infectious, metabolic, and autoimmune causes, have been identified as contributing to POI [2]. Deleted in Azoospermia-like (DAZL, or Dazla), a germ line-specific gene, encodes an RNA-binding protein that plays a crucial role...

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PMID: 39872666
DOI: 10.1093/lifemedi/lnae007

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