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Article

Targeted Next-Generation Sequencing Indicates a Frequent Oligogenic Involvement in Primary Ovarian Insufficiency Onset.

Frontiers in endocrinology - 1 Jan 2021

Rossetti Raffaella, Moleri Silvia, Guizzardi Fabiana, Gentilini Davide, Libera Laura, Marozzi Anna, Moretti Costanzo, Brancati Francesco, Bonomi Marco, Persani Luca

Abstract excerpt

Primary ovarian insufficiency (POI) is one of the major causes of female infertility associated with the premature loss of ovarian function in about 3.7% of women before the age of 40. This disorder is highly heterogeneous and can manifest with a wide range of clinical phenotypes, ranging from ovarian dysgenesis and primary amenorrhea to post-pubertal secondary amenorrhea, with elevated serum gonadotropins and...

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Identifiers

PMID: 34803902
DOI: 10.3389/fendo.2021.664645
PMCID: PMC8600266

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