Article
Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model.
Acta pharmacologica Sinica - 1 May 2025
Guo Qing, Gan Jun, Wang En-Ze, Wei Yu-Ming, Xu Jie, Xu Yun, Zhang Fei-Fei, Cui Meng, Jia Meng-Xing, Kong Ming-Jian, Tang Qiong-Yao, Zhang Zhe
Abstract excerpt
Patients suffering epilepsy caused by the gain-of-function mutants of the hKCNT1 potassium channels are drug refractory. In this study, we cloned a novel human KCNT1B channel isoform using the brain cDNA library and conducted patch-clamp and molecular docking analyses to characterize the pharmacological properties of the hKCNT1B channel using thirteen drugs. Among cinchona alkaloids, we found that hydroquinine...
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