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Article

Mutant KRAS and CK2 Cooperatively Stimulate SLC16A3 Activity to Drive Intrahepatic Cholangiocarcinoma Progression.

Cancer research - 3 Apr 2025

Chen Ran, Ma Cuihong, Qian Haoran, Xie Xinyu, Zhang Yuxue, Lu Dayun, Hu Shunjie, Zhang Mao, Liu Fen, Zou Yunhao, Gao Qiang, Zhou Hu, Liu Hailong, Lin Moubin, Ge Gaoxiang, Gao Daming

Abstract excerpt

Intrahepatic cholangiocarcinoma (iCCA) is a lethal malignancy affecting the liver and biliary system. Enhanced understanding of the pathogenic mechanisms underlying iCCA tumorigenesis and the discovery of appropriate therapeutic targets are imperative to improve patient outcomes. In this study, we investigated the functions and regulations of solute carrier family 16 member 3 (SLC16A3), which has been reported to...

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Source

Identifiers

PMID: 39854318
DOI: 10.1158/0008-5472.CAN-24-2097

Genes

SLC16A3
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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