Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates

9 Jan 2025

Abstract excerpt

Antibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from natural substrates of these efflux systems. In this work, we aimed to elucidate the natural substrates of the clinically relevant Mex efflux pumps of Pseudomonas aeruginosa by an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Bacterial biofilms and quorum sensing
Share to Mycobacterium research and diagnosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39850140
DOI: 10.3389/fmicb.2024.1512472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substratesPMID 39850140Read ↗

Evaluating the Link Between Efflux Pump Expression and Motility Phenotypes in <i>Pseudomonas aeruginosa</i> Treated with Virulence InhibitorsSemantic proximity Read ↗

The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug EfficacySemantic proximity Read ↗

MexXY multidrug efflux system of Pseudomonas aeruginosaSemantic proximity Read ↗

Untargeted LC-MS Metabolomics Differentiates Between Virulent and Avirulent Clinical Strains of Pseudomonas aeruginosa.Semantic proximity Read ↗

PAMDB: a comprehensive Pseudomonas aeruginosa metabolome databaseSemantic proximity Read ↗

Non-interchangeable functions of efflux transporters of Pseudomonas aeruginosa in survival under infection-associated stressSemantic proximity Read ↗

Regulation, structure, and activity of the Pseudomonas aeruginosa MexXY efflux systemSemantic proximity Read ↗

Decoding MexB efflux pump genes: structural, molecular, and phylogenetic analysis of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosaSemantic proximity Read ↗

Efflux-mediated Multidrug Resistance in Critical Gram-negative Bacteria and Natural Efflux Pump InhibitorsSemantic proximity Read ↗

Evolutionary loss of an antibiotic efflux pump increases Pseudomonas aeruginosa quorum sensing mediated virulence in vivoSemantic proximity Read ↗

Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative BacteriaSemantic proximity Read ↗

Efflux Pumps: Their Role in Antibacterial Drug DiscoverySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.