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Integration of multi-omics data to unveil the molecular landscape and role of piRNAs in early-onset colorectal cancer

29 Apr 2025

Abstract excerpt

BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC) (< 50 years) has been steadily rising, with a parallel increase in metastatic and invasive cases. To elucidate the molecular mechanisms underlying this aggressive phenotype, we performed comprehensive multi-omics profiling to delineate the distinct features of EOCRC, with a focus on key drivers of metastatic and invasive potential. METHODS: We...

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PMID: 40301858
DOI: 10.1186/s12916-025-04074-2

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