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Article

Hypermethylation of Hif3a and Ifltd1 is associated with atrial remodeling in pressure-overload murine model

21 Jan 2025

Abstract excerpt

Atrial remodeling is a major pathophysiological mechanism of atrial fibrillation (AF). Atrial remodeling progresses with aging and background diseases, including hypertension, heart failure, and AF itself. However, its mechanism of action and reversibility have not been completely elucidated. In this study, we investigated the involvement of DNA methylation in atrial remodeling. Mice underwent transverse aortic...

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PMID: 39837857
DOI: 10.1038/s41598-025-85382-8

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