Article
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.
Nature immunology - 12 Oct 2011
Ramirez-Carrozzi Vladimir, Sambandam Arivazhagan, Luis Elizabeth, Lin Zhongua, Jeet Surinder, Lesch Justin, Hackney Jason, Kim Janice, Zhou Meijuan, Lai Joyce, Modrusan Zora, Sai Tao, Lee Wyne, Xu Min, Caplazi Patrick, Diehl Lauri, de Voss Jason, Balazs Mercedesz, Gonzalez Lino, Singh Harinder, Ouyang Wenjun, Pappu Rajita
Abstract excerpt
Interleukin 17C (IL-17C) is a member of the IL-17 family that is selectively induced in epithelia by bacterial challenge and inflammatory stimuli. Here we show that IL-17C functioned in a unique autocrine manner, binding to a receptor complex consisting of the receptors IL-17RA and IL-17RE, which was preferentially expressed on tissue epithelial cells. IL-17C stimulated epithelial inflammatory responses,...
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