Article
Identification of a vimentin-expressing α-cell phenotype in CF and normal pancreas.
The Journal of endocrinology - 1 Mar 2025
Kattner Nicole, Hang Yan, Krentz Nicole A J, Russell Lydia A, Palmer Matthew, Flaxman Christine, Plett Nadine, Coulthard Rowan, Al-Selwi Yara, Dyson Nicola, Honkanen-Scott Minna, Kim Seung K, Tiniakos Dina, Klöppel Günter, Richardson Sarah J, Shaw James A M
Abstract excerpt
Endocrine dysfunction and diabetes can develop secondary to fibrotic diseases within the pancreas, including cystic fibrosis (CF). A phenotypic shift within epithelial cells has been recognised in association with pro-fibrotic signalling. We sought evidence of endocrine cell epithelial-to-mesenchymal transition in CF and non-CF pancreas. Post-mortem pancreatic sections from 24 people with CF and 10 organ donors...
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