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Article

Use of whole genome sequencing to identify low-frequency mutations in SARS-CoV-2 patients treated with remdesivir.

Influenza and other respiratory viruses - 1 Sept 2023

Nirmalarajah Kuganya, Yim Winfield, Aftanas Patryk, Li Angel X, Shigayeva Altynay, Yip Lily, Zhong Zoe, McGeer Allison J, Maguire Finlay, Mubareka Samira, Kozak Robert

Abstract excerpt

BACKGROUND: Remdesivir (RDV) has been shown to reduce hospitalization and mortality in COVID-19 patients. Resistance mutations caused by RDV are rare and have been predominantly reported in patients who are on prolonged therapy and immunocompromised. We investigate the effects of RDV treatment on intra-host SARS-CoV-2 diversity and low-frequency mutations in moderately ill hospitalized COVID-19 patients and...

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Identifiers

PMID: 37752062
DOI: 10.1111/irv.13179
PMCID: PMC10522481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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