Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn's disease.

doi:10.1080/19490976.2025.2452250

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Article

Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn's disease.

Gut microbes - 1 Dec 2025

Budzinski Lisa, Kang Gi-Ung, Riedel René, Sempert Toni, Lietz Leonie, Maier René, Büttner Janine, Bochow Bettina, Tordai Marcell T, Shah Aayushi, Abbas Amro, Momtaz Tanisha, Krause Jannike L, Kempkens Robin, Lehman Katrin, Heinz Gitta A, Benken Anne E, Bartsch Stefanie, Necke Kathleen, Hoffmann Ute, Mashreghi Mir-Farzin, Biesen Robert, Kallinich Tilmann, Alexander Tobias, Jessen Bosse, Weidinger Carl, Siegmund Britta, Radbruch Andreas, Schirbel Anja, Moser Benjamin, Chang Hyun-Dong

Abstract excerpt

IgA-coated fractions of the intestinal microbiota of Crohn's disease (CD) patients have been shown to contain taxa that hallmark the compositional dysbiosis in CD microbiomes. However, the correlation between other cellular properties of intestinal bacteria and disease has not been explored further, especially for features that are not directly driven by the host immune-system, e.g. the expression of surface...

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PMID: 39815413
DOI: 10.1080/19490976.2025.2452250
PMCID: PMC11740678

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