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Article

Redefining macrophage phenotypes after spinal cord injury: An open data approach.

Experimental neurology - 1 Jun 2025

Stapenhorst França Fernanda, Gensel John C

Abstract excerpt

Spinal cord injury (SCI) triggers intraspinal inflammation through an influx of blood-derived inflammatory cells such as neutrophils and monocyte-derived macrophages. Macrophages play a complex role in SCI pathophysiology ranging from potentiating secondary injury to facilitating recovery and wound healing. In vitro, macrophages have been classified as having a pro-inflammatory, M1 phenotype, or a regenerative,...

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Macrophages
Mice
Mice, Inbred C57BL
Phenotype
Single-Cell Analysis
Spinal Cord Injuries

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PMID: 40113007
DOI: 10.1016/j.expneurol.2025.115222
PMCID: PMC13122588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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