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Article

Gut microbiota may influence Sjögren's syndrome risk through immune cell mediation: A Mendelian randomization analysis.

Medicine - 29 May 2026

Yang Jie, Chen Jide, Huang Liyuan, Wang Zhixue, Cheng Yue

Abstract excerpt

Sjögren's syndrome (SS) pathogenesis involves complex interactions between gut microbiota and immune dysregulation, yet causal relationships remain not fully elucidated. This Mendelian randomization (MR) study investigates whether gut microbiota influences SS risk through immune cell mediation. We performed univariable and mediation MR analyses using genome-wide association study data from FinnGen (3309 SS cases,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42216352
DOI: 10.1097/MD.0000000000049063
PMCID: PMC13225578

Genes

CD28
CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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