Article
Lineage-Specific Relapse Prediction After Haploidentical Transplantation With Post-Transplant Cyclophosphamide Based on Recipient HLA-B-Leader Genotype and HLA-C-Group KIR Ligand.
Transplantation and cellular therapy - 1 Sept 2022
Solomon Scott R, Aubrey Michael T, Zhang Xu, Jackson Katelin C, Roark Christina L, Freed Brian M, Morris Lawrence E, Holland H Kent, Solh Melhem M, Bashey Asad
Abstract excerpt
The role of NK cell alloreactivity on outcomes after T cell-replete haploidentical donor transplantation (HIDT) remains uncertain. After transplantation, newly formed NK cells are licensed through interactions of donor inhibitory KIR (iKIR) and NKG2A receptors with their cognate ligands on recipient cells. Donor NKG2A recognizes HLA-E bound by recipient HLA class I leader peptides, a process requiring methionine...
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