Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.

doi:10.1172/JCI69636

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Article

Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.

The Journal of clinical investigation - 1 Dec 2013

Lam Hilaire C, Cloonan Suzanne M, Bhashyam Abhiram R, Haspel Jeffery A, Singh Anju, Sathirapongsasuti J Fah, Cervo Morgan, Yao Hongwei, Chung Anna L, Mizumura Kenji, An Chang Hyeok, Shan Bin, Franks Jonathan M, Haley Kathleen J, Owen Caroline A, Tesfaigzi Yohannes, Washko George R, Quackenbush John, Silverman Edwin K, Rahman Irfan, Kim Hong Pyo, Mahmood Ashfaq, Biswal Shyam S, Ryter Stefan W, Choi Augustine M K

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) involves aberrant airway inflammatory responses to cigarette smoke (CS) that are associated with epithelial cell dysfunction, cilia shortening, and mucociliary clearance disruption. Exposure to CS reduced cilia length and induced autophagy in vivo and in differentiated mouse tracheal epithelial cells (MTECs). Autophagy-impaired (Becn1+/- or Map1lc3B-/-) mice and MTECs...

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Identifiers

PMID: 24200693
DOI: 10.1172/JCI69636
PMCID: PMC3859407

Genes

HDAC6
MCC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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