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Article

Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.

Disease models & mechanisms - 1 Jan 2000

Wempe Frank, De-Zolt Silke, Koli Katri, Bangsow Thorsten, Parajuli Nirmal, Dumitrascu Rio, Sterner-Kock Anja, Weissmann Norbert, Keski-Oja Jorma, von Melchner Harald

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Cigarette smoking has been identified as one of the major risk factors and several predisposing genetic factors have been implicated in the pathogenesis of COPD, including a single nucleotide polymorphism (SNP) in the latent transforming growth factor (TGF)-beta binding protein 4 (Ltbp4)-encoding gene. Consistent...

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Identifiers

PMID: 20106877
DOI: 10.1242/dmm.004234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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