Article
A new genomic framework to categorize pediatric acute myeloid leukemia.
Nature genetics - 1 Feb 2024
Umeda Masayuki, Ma Jing, Westover Tamara, Ni Yonghui, Song Guangchun, Maciaszek Jamie L, Rusch Michael, Rahbarinia Delaram, Foy Scott, Huang Benjamin J, Walsh Michael P, Kumar Priyadarshini, Liu Yanling, Yang Wenjian, Fan Yiping, Wu Gang, Baker Sharyn D, Ma Xiaotu, Wang Lu, Alonzo Todd A, Rubnitz Jeffrey E, Pounds Stanley, Klco Jeffery M
Abstract excerpt
Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific driver alterations, many of which are underrepresented in the current classification schemas. To comprehensively define the genomic landscape of pAML, we systematically categorized 887 pAML into 23 mutually distinct molecular categories, including new major entities such as UBTF or BCL11B, covering 91.4% of the cohort....
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