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Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo

22 Jul 2024

Abstract excerpt

Abstract Endoplasmic reticulum (ER) remodeling is vital for cellular organization. ER-phagy, a selective autophagy targeting ER, plays an important role in maintaining ER morphology and function. The FAM134 protein family, including FAM134A, FAM134B, and FAM134C, mediates ER-phagy. While FAM134B mutations are linked to hereditary sensory and autonomic neuropathy in humans, the physiological role of the other...

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PMID: 39039299
DOI: 10.1038/s44319-024-00213-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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