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Article

Dissecting the mediating role of cytokines in the interaction between immune traits and sepsis: insights from comprehensive mendelian randomization.

Frontiers in immunology - 1 Jan 2024

Zheng Xiangtao, Wang Yihui, Wang Yuming, Wang Xiaofeng, Pei Lei, Zhao Shanzhi, Gong Fangchen, Li Ranran, Liu Huan, Liu Wenbin, Mao Enqiang, Yang Zhitao, Chen Erzhen, Chen Ying

Abstract excerpt

Background: Sepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infection, yet the potential causal relationship between the immunophenotype and sepsis remains unclear. Methods: Genetic variants associated with the immunophenotype served as instrumental variables (IVs) in Mendelian randomization (MR) to elucidate the causal impact of the immunophenotype on three sepsis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39076981
DOI: 10.3389/fimmu.2024.1417716
PMCID: PMC11284126

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