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Article

Effects of genetic mutations on left ventricular myocardial mechanics and fibrosis patterns in hypertrophic cardiomyopathy.

Scientific reports - 4 Jan 2025

Kim Minjeong, Kim Yoonjung, Chung Hyemoon, Seo Jiwon, Park Chul Hwan, Kim Tae Hoon, Rim Se-Joong, Lee Kyung-A, Choi Eui-Young

Abstract excerpt

Myocyte disarray and fibrosis are underlying pathologies of hypertrophic cardiomyopathy (HCM) caused by genetic mutations. However, the extent of their contributions has not been extensively evaluated. In this study, we investigated the effects of genetic mutations on myofiber function and fibrosis patterns in HCM. A total of 133 patients with HCM underwent chamber geometry, late gadolinium enhancement (LGE), and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Magnetic Resonance Imaging, Cine

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Source

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Identifiers

PMID: 39755839
DOI: 10.1038/s41598-025-85201-0
PMCID: PMC11700167

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