Article
Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathy.
Circulation. Cardiovascular genetics - 1 Aug 2009
Ho Carolyn Y, Carlsen Christian, Thune Jens Jakob, Havndrup Ole, Bundgaard Henning, Farrohi Faranak, Rivero Jose, Cirino Allison L, Andersen Paal Skytt, Christiansen Michael, Maron Barry J, Orav E John, Køber Lars
Abstract excerpt
BACKGROUND: Genetic testing identifies sarcomere mutation carriers (G+) before clinical diagnosis of hypertrophic cardiomyopathy (HCM), allowing characterization of initial disease manifestations. Previous studies demonstrated that impaired relaxation develops before left ventricular hypertrophy (LVH). The precise impact of sarcomere mutations on systolic function in early and late disease is unclear. METHODS AND...
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