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Article

SARC Gene Mutation Is Associated With Myocardial Fibrosis Measured by Histopathology and Cardiac Magnetic Resonance in Patients With Hypertrophic Cardiomyopathy.

Journal of the American Heart Association - 7 Mar 2023

Huang Manyun, Zhang Jian, Song Changpeng, Wang Shuiyun, Zhou Zhou, Wang Hongyue, Zhao Shihua, Yin Kunlun, Li Li, Yang Shujuan, Zheng Xinxin, Lu Jie, Huang Xiaohong

Abstract excerpt

Background Sarcomere gene mutation and myocardial fibrosis are both associated with poorer clinical outcomes in patients with hypertrophic cardiomyopathy (HCM). The aim of this study was to determine the relationship between sarcomere gene mutation and myocardial fibrosis measured by both histopathology and cardiac magnetic resonance (CMR). Methods and Results Two hundred twenty-seven patients with HCM who...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36802920
DOI: 10.1161/JAHA.122.028293
PMCID: PMC10111446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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