Whole genome sequencing of Yersinia pestis isolates from Central Asian natural plague foci revealed the role of adaptation to different hosts and environmental conditions in shaping specific genotypes.

doi:10.1371/journal.pntd.0013533

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Whole genome sequencing of Yersinia pestis isolates from Central Asian natural plague foci revealed the role of adaptation to different hosts and environmental conditions in shaping specific genotypes.

PLoS neglected tropical diseases - 1 Sept 2025

Abdirassilova Aigul A, Yessimseit Duman T, Kassenova Altynai K, Abdeliyev Beck Z, Zhumadilova Zauresh B, Tokmurziyeva Gulnara Zh, Kovaleva Galina G, Abdel Ziyat Zh, Meka-Mechenko Tatiyana V, Umarova Saule K, Begimbayeva Elmira Zh, Agzam Sanzhar D, Motin Vladimir L, Reva Oleg N, Rysbekova Altyn K

Abstract excerpt

The genetic diversity and biovar classification of Yersinia isolates from Central Asia were investigated using whole-genome sequencing. In total, 98 isolates from natural plague foci were sequenced using the MiSeq platform. Computational pipelines were developed for accurate assembly of Y. pestis replicons, including small cryptic plasmids, and for identifying genetic polymorphisms. A panel of 99 diagnostic...

Read the complete abstract on PubMed

Topics

Yersinia pestis
Plague
Whole Genome Sequencing
Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome, Bacterial

Plasmids

Phylogeny

Humans

Asia, Central

Genetic Variation

Animals

Polymorphism, Genetic

Adaptation, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 40938972
DOI: 10.1371/journal.pntd.0013533
PMCID: PMC12445494

Genes

MED1

Provenance

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