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Article

Titin gene mutations enhance radiotherapy efficacy via modulation of tumour immune microenvironment in rectum adenocarcinoma.

Clinical and translational medicine - 1 Jan 2025

Liu Hengchang, Liu Jialiang, Guan Xu, Zhao Zhixun, Cheng Pu, Chen Haipeng, Jiang Zheng, Wang Xishan

Abstract excerpt

OBJECTIVE: This study investigates the impact of Titin (TTN) gene mutations on radiotherapy sensitivity in rectum adenocarcinoma (READ) by examining changes in the tumour immune microenvironment. METHODS: Data on gene expression and mutations in READ were obtained from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases. Bioinformatics analysis explored the correlation...

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Identifiers

PMID: 39748197
DOI: 10.1002/ctm2.70123
PMCID: PMC11695211

Genes

TTN
CD4
JUN

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