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Article

Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene.

Nature communications - 19 Jan 2023

Kentistou Katherine A, Luan Jian'an, Wittemans Laura B L, Hambly Catherine, Klaric Lucija, Kutalik Zoltán, Speakman John R, Wareham Nicholas J, Kendall Timothy J, Langenberg Claudia, Wilson James F, Joshi Peter K, Morton Nicholas M

Abstract excerpt

Obesity remains an unmet global health burden. Detrimental anatomical distribution of body fat is a major driver of obesity-mediated mortality risk and is demonstrably heritable. However, our understanding of the full genetic contribution to human adiposity is incomplete, as few studies measure adiposity directly. To address this, we impute whole-body imaging adiposity phenotypes in UK Biobank from the 4,366...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36658113
DOI: 10.1038/s41467-022-35563-0
PMCID: PMC9852585

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