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Article

Heterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats.

Scientific reports - 2 Jan 2025

Motooka Yashiro, Tanaka Hideaki, Maeda Yuki, Katabuchi Misako, Mashimo Tomoji, Toyokuni Shinya

Abstract excerpt

Tumor suppressor BRCA2 executes homologous recombination to repair DNA double-strand breaks in collaboration with RAD51, involving exon 11 and 27. Exon 11 constitutes a region where pathogenic variants (PVs) accumulate, and mutations in this region are known to contribute to carcinogenesis. However, the impact of the heterozygous PVs of BRCA2 exon 11 on the life quality beyond cancer risk, including male...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39747609
DOI: 10.1038/s41598-024-84184-8
PMCID: PMC11696240

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