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A genome-wide association study of high-sensitivity C-reactive protein in a large Korean population highlights its genetic relationship with cholesterol metabolism.

Scientific reports - 2 Jan 2025

Oh Kwangyeon, Yuk Minju, Yang Soyoun, Youn Jiyeong, Dong Qian, Wang Zhaoming, Song Nan

Abstract excerpt

High-sensitivity C-reactive protein (hsCRP) is a representative biomarker of systemic inflammation and is associated with numerous chronic diseases. To explore the biological pathways and functions underlying chronic inflammation, we conducted a genome-wide association study (GWAS) and several post-GWAS analyses of the hsCRP levels. This study was performed on data from 71,019 Koreans and is one of the largest...

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Identifiers

PMID: 39747571
DOI: 10.1038/s41598-024-84466-1
PMCID: PMC11696572

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