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Dynamic interplay of autophagy and membrane repair during Mycobacterium tuberculosis Infection

2 Jan 2025

Abstract excerpt

Autophagy plays a crucial role in the host response to Mycobacterium tuberculosis (Mtb) infection, yet the dynamics and regulation of autophagy induction on Mtb-containing vacuoles (MCVs) remain only partially understood. We employed time-lapse confocal microscopy to investigate the recruitment of LC3B (LC3), a key autophagy marker, to MCVs at the single cell level with our newly developed workflow for single...

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PMID: 39746091
DOI: 10.1371/journal.ppat.1012830

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