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Article

The role of ATG5 beyond Atg8ylation and autophagy

25 Oct 2023

Abstract excerpt

ATG5 plays a pivotal role in membrane Atg8ylation, influencing downstream processes encompassing canonical autophagy and noncanonical processes. Remarkably, genetic ablation of ATG5 in myeloid cells leads to an exacerbated pathological state in murine models of tuberculosis, characterized by an early surge in mortality much more severe when compared to the depletion of other components involved in Atg8ylation or...

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PMID: 37876292
DOI: 10.1080/15548627.2023.2273703

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