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[Genetic Mutation Profile and Risk Stratification of Cytogenetically Normal Acute Myeloid Leukemia with CEBPA-bZIP Mutations Based on Multi-Gene Sequencing].

Zhongguo shi yan xue ye xue za zhi - 1 Dec 2024

Cao Lei-Ming, Liao Ming-Yue, Zhou Ya-Lan, Jiang Hao, Jiang Qian, Chang Ying-Jun, Xu Lan-Ping, Zhang Xiao-Hui, Huang Xiao-Jun, Ruan Guo-Rui

Abstract excerpt

OBJECTIVE: To evaluate the gene mutation profile and prognostic significance of adult cytogenetically normal acute myeloid leukemia (CN-AML) with CEBPA-bZIP mutation. METHODS: Targeted sequencing was implemented on the diagnostic bone marrow DNA samples of 141 adult CN-AML subjects with CEBPA-bZIP mutation. The nomogram model for leukemia-free survival (LFS) rate was generated by combining genetic abnormalities...

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PMID: 39743244
DOI: 10.19746/j.cnki.issn.1009-2137.2024.06.001

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