An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup.

doi:10.1126/scitranslmed.adr2012

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Article

An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup.

Science translational medicine - 1 Jan 2025

Gower Mark, Li Ximing, Aguilar-Navarro Alicia G, Lin Brian, Fernandez Minerva, Edun Gibran, Nader Mursal, Rondeau Vincent, Arruda Andrea, Tierens Anne, Eames Seffernick Anna, Pölönen Petri, Durocher Juliette, Wagenblast Elvin, Yang Lin, Lee Ho Seok, Mullighan Charles G, Teachey David, Rashkovan Marissa, Tremblay Cedric S, Herranz Daniel, Itkin Tomer, Loghavi Sanam, Dick John E, Schwartz Gregory, Perusini Maria Agustina, Sibai Hassan, Hitzler Johann, Gruber Tanja A, Minden Mark, Jones Courtney L, Dolgalev Igor, Jahangiri Soheil, Tikhonova Anastasia N

Abstract excerpt

T-lineage acute lymphoblastic leukemia (ALL) is an aggressive cancer comprising diverse subtypes that are challenging to stratify using conventional immunophenotyping. To gain insights into subset-specific therapeutic vulnerabilities, we performed an integrative multiomics analysis of bone marrow samples from newly diagnosed T cell ALL, early T cell precursor ALL, and T/myeloid mixed phenotype acute leukemia....

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PMID: 39742502
DOI: 10.1126/scitranslmed.adr2012

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