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Article

Comprehensive omics-based classification system in adult patients with B-cell acute lymphoblastic leukemia.

Molecular oncology - 1 Dec 2025

Song Yang, Liu Ting, Hao Qishan, Fang Qiuyun, Gong Xiaoyuan, Li Yan, Tian Zheng, Wei Hui, Wang Min, Wang Jianxiang, Cheng Tao, Mi Yingchang

Abstract excerpt

B-cell acute lymphoblastic leukemia (B-ALL) is a highly heterogeneous disease with a challenging prognosis, particularly in adult patients. We enrolled 88 adult B-ALL patients with transcriptomic and mutation profiles for classification system identification, and a comprehensive system for B-ALL patients (COMBAT) was developed. COMBAT stratified patients into three cohorts: (1) COMBAT1, characterized by high...

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PMID: 40388565
DOI: 10.1002/1878-0261.70053
PMCID: PMC12688170

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