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Article

Comprehensive characterization of MCL-1 in patients with colorectal cancer: Expression, molecular profiles, and outcomes.

International journal of cancer - 15 Apr 2025

Mittal Pooja, Battaglin Francesca, Baca Yasmine, Xiu Joanne, Farrell Alex, Soni Shivani, Lo Jae Ho, Torres-Gonzalez Lesly, Algaze Sandra, Jayachandran Priya, Ashouri Karam, Wong Alexandra, Zhang Wu, Yu Jian, Zhang Lin, Weinberg Benjamin A, Lou Emil, Shields Anthony F, Goldberg Richard M, Marshall John L, Goel Sanjay, Singh Indrakant K, Lenz Heinz-Josef

Abstract excerpt

Myeloid cell leukemia 1 (MCL-1) is a member of the B-cell lymphoma 2 protein family and has anti-apoptotic functions. Deregulation of MCL-1 has been reported in several cancers, including lung and breast cancer. In the present study, the association of MCL-1 expression with molecular features in colorectal cancer (CRC) has been highlighted. CRC samples from Caris Life Sciences (Phoenix, AZ) were analyzed using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39740007
DOI: 10.1002/ijc.35304
PMCID: PMC11826129

Genes

APC
ASXL1
ATM
BCOR
CDKN1B
GNAS
KDM6A
KMT2D
KRAS
MSH6
NRAS
RNF43
SPEN
STK11
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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