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Article

AI allows pre-screening of FGFR3 mutational status using routine histology slides of muscle-invasive bladder cancer.

Nature communications - 30 Dec 2024

Bannier Pierre-Antoine, Saillard Charlie, Mann Philipp, Touzot Maxime, Maussion Charles, Matek Christian, Klümper Niklas, Breyer Johannes, Wirtz Ralph, Sikic Danijel, Schmitz-Dräger Bernd, Wullich Bernd, Hartmann Arndt, Försch Sebastian, Eckstein Markus

Abstract excerpt

Pathogenic activating mutations in the fibroblast growth factor receptor 3 (FGFR3) drive disease maintenance and progression in urothelial cancer. 10-15% of muscle-invasive and metastatic urothelial cancer (MIBC/mUC) are FGFR3-mutant. Selective targeting of FGFR3 hotspot mutations with tyrosine kinase inhibitors (e.g., erdafitinib) is approved for mUC and requires FGFR3 mutational testing. However, current...

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Identifiers

PMID: 39738108
DOI: 10.1038/s41467-024-55331-6
PMCID: PMC11685973

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