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Article

Liquid biopsy based on multi-targeted capture of urinary tumor DNA combined with machine learning to detect urothelial carcinoma: a multicenter prospective study.

International urology and nephrology - 1 Apr 2026

Tang Chaozhi, Wang Tianlong, Luo Huarong, Xue Jingdong, Zhu Miaojun, Hong Zhe, Ding Fang, Zhang Fengwu, Zhu Yihao, Tan Ruoying, Wu Denglong

Abstract excerpt

PURPOSE: Diagnostics for urothelial carcinoma have low sensitivity, thereby negatively impacting diagnostic outcomes. Herein, we present BiovueUro, a machine learning-based urine DNA biomarker tool for urothelial carcinoma detection. We developed BiovueUro to monitor DNA mutation and methylation in urine samples. METHODS: The study involved 63 patients with malignant urothelial carcinoma, 13 patients with benign...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40996609
DOI: 10.1007/s11255-025-04813-7

Genes

FGFR3
NRN1
PIK3CA
POU4F2
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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