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Spatial transcriptomic analysis drives PET imaging of tight junction protein expression in pancreatic cancer theranostics

30 Dec 2024

Abstract excerpt

Molecular imaging using positron emission tomography (PET) provides sensitive detection and mapping of molecular targets. While cancer-associated fibroblasts and integrins have been proposed as targets for imaging of pancreatic ductal adenocarcinoma (PDAC), herein, spatial transcriptomics and proteomics of human surgical samples are applied to select PDAC targets. We find that selected cancer cell surface markers...

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PMID: 39737976
DOI: 10.1038/s41467-024-54761-6

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