Understanding antiphospholipid syndrome clinical phenotypes with the guidance of antiphospholipid antibody-related pathogenic mechanisms.

Abstract excerpt

Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by thrombosis, microvascular disease, pregnancy morbidity, or non-thrombotic manifestations in patients with antiphospholipid antibodies. The mechanistic differentiation of these clinical phenotypes has diagnostic and therapeutic implications. Across APS phenotypes, a shared set of effector mechanisms are: a) endothelial activation...

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