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Article

Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions

7 Sept 2011

Abstract excerpt

Natural killer (NK) cells are recruited into the uterine stroma during establishment of the hemochorial placenta and are proposed regulators of uterine spiral artery remodeling. Failures in uterine spiral artery remodeling are linked to diseases of pregnancy. This prompted an investigation of the involvement of NK cells in placentation. NK cell depletion decreased the delivery of proangiogenic factors and delayed...

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Share to Maternal and fetal healthcare
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21900602
DOI: 10.1073/pnas.1109478108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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