Article
Apolipoprotein E epsilon4 allele is associated with better performance language and visual memory in spinocerebellar ataxia type 3.
European journal of neurology - 1 Jan 2025
Chen Xuanyu, Lin Kunxin, Ye Zhixian, Qiu Liangliang, Qiu Yusen, Yuan Ruying, Yu Xintong, Huang Chunyu, Cheng Bi, Lin Wei, Lai Tianmin, Chen Wanjin, Wang Ning, Gan Shirui, Su Qiuni, Fu Ying
Abstract excerpt
BACKGROUND: The regulatory role of the apolipoprotein E (APOE) ε4 allele in the clinical manifestations of spinocerebellar ataxia type 3 (SCA3) remains unclear. This study aimed to evaluate the impact of the APOE ε4 allele on cognitive and motor functions in SCA3 patients. METHODS: This study included 281 unrelated SCA3 patients and 182 controls. APOE genotypes were analyzed using PCR amplification combined with...
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