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KRAS Mutations in Cholangiocarcinoma: Prevalence, Prognostic Value, and KRAS G12/G13 Detection in Cell-Free DNA.

Cancer genomics & proteomics - 1 Jan 2000

Thongyoo Pitchasak, Chindaprasirt Jarin, Aphivatanasiri Chaiwat, Intarawichian Piyapharom, Kunprom Waritta, Kongpetch Sarinya, Techasen Anchalee, Loilome Watcharin, Namwat Nisana, Titapun Attapol, Jusakul Apinya

Abstract excerpt

BACKGROUND/AIM: Cholangiocarcinoma (CCA) is an aggressive hepatobiliary malignancy characterized by genomic heterogeneity. KRAS mutations play a significant role in influencing patient prognosis and guiding therapeutic decision-making. This study aimed to determine the prevalence and prognostic significance of KRAS mutations in CCA, asses the detection of KRAS G12/G13 mutations in plasma cell-free DNA (cfDNA),...

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Aged
Bile Duct Neoplasms
Biomarkers, Tumor
Cell-Free Nucleic Acids
Cholangiocarcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 39730186
DOI: 10.21873/cgp.20492
PMCID: PMC11696325

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