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Genotyping of circulating tumor DNA in cholangiocarcinoma reveals diagnostic and prognostic information

13 Sept 2019

Abstract excerpt

Diagnosis of Cholangiocarcinoma (CCA) is difficult, thus a noninvasive approach towards (i) assessing and (ii) monitoring the tumor-specific mutational profile is desirable to improve diagnosis and tailor treatment. Tumor tissue and corresponding ctDNA samples were collected from patients with CCA prior to and during chemotherapy and were subjected to deep sequencing of 15 genes frequently mutated in CCA. A set...

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PMID: 31519967
DOI: 10.1038/s41598-019-49860-0

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