Article
Complex Genetic Evolution and Treatment Challenges in Myeloid Neoplasms: A Case of Persistent t(2;3)(p15~23;q26)/MECOM Rearrangement, SF3B1 Mutation, and Transient TNIP1::PDGFRB Chimera.
Cancer genomics & proteomics - 1 Jan 2000
Andersen Kristin, Tjønnfjord Geir E, Hestdalen Malu Lian, Spetalen Signe, Panagopoulos Ioannis
Abstract excerpt
BACKGROUND/AIM: Myelodysplastic syndromes (MDSs) are clonal bone marrow disorders characterized by ineffective hematopoiesis. They are classified based on morphology and genetic alterations, with SF3B1 variants linked to favorable prognosis and MECOM rearrangements associated with poor outcomes. The combined effects of these alterations remain unclear. We report an MDS patient carrying both SF3B1 and MECOM...
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