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Article

RICTOR Gene Amplification is Correlated with Metastasis and Therapeutic Resistance in Triple-Negative Breast Cancer

23 May 2018

Abstract excerpt

Triple-negative breast cancer (TNBC) is characterized by its aggressive behavior, metastasis and lack of targeted therapies. Herein, we discuss the clinical, histopathological and genetic profile of a woman diagnosed with TNBC. Since the patient had no durable response to chemotherapy, a genetic profiling was carried out. Next-generation sequencing analysis of 592 genes showed a missense mutation, p.E545A in...

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PMID: 29790419
DOI: 10.2217/pgs-2018-0019

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